| # | Swimmer | Team | Seed | Time | Diff |
| 1 |
Lee, Meghan R (18)
|
MDEST |
4:59.83 |
5:01.24 |
1.41 |
| 2 |
Helminiak, Katherine E (16)
|
MDMAS |
5:28.89 |
5:21.73 |
-7.16 |
| 3 |
Florio, Rachel V (18)
|
MDEST |
5:10.26 |
5:24.79 |
14.53 |
| 4 |
McDaniels, Madison T (16)
|
MDMAS |
5:25.19 |
5:36.98 |
11.79 |
| 5 |
DeMario, Emma R (15)
|
MDCCY |
5:55.02 |
5:38.90 |
-16.12 |
| 6 |
Cuchna, Francesca M (17)
|
MDMAS |
5:49.77 |
5:46.50 |
-3.27 |
| 7 |
Miner, Ailee G (17)
|
MDFAST |
5:55.00 |
6:08.96 |
13.96 |
| 8 |
Mazur, Karolina T (16)
|
MDEST |
6:00.02 |
6:12.33 |
12.31 |
| 9 |
Klopouh, Milana S (16)
|
MDEST |
6:09.21 |
6:17.30 |
8.09 |
| 10 |
Rice, Stephanie M (15)
|
MDMAS |
6:21.43 |
6:20.15 |
-1.28 |
| 11 |
St. Pierre, Shannon M (15)
|
MDCCY |
6:34.11 |
6:23.41 |
-10.70 |
| 12 |
Nagle, Ashleigh M (17)
|
MDCAA |
|
6:25.88 |
- |
| 13 |
Machen, Ella Katherine H (16)
|
MDFAST |
6:28.19 |
6:31.94 |
3.75 |
| 14 |
Will, Chelsea M (15)
|
MDMAS |
|
7:11.77 |
- |
| 15 |
Bell, Amayah G (16)
|
MDEST |
|
7:58.84 |
- |